Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, which suggests a differential implication of mRNP biogenesis factors in genome integrity in yeast and humans. We show that human THO depletion impairs transcription elongation...

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Detalles Bibliográficos
Autores principales: Domínguez-Sánchez, María S., Barroso, Sonia, Gómez-González, Belén, Luna, Rosa, Aguilera, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228816/
https://www.ncbi.nlm.nih.gov/pubmed/22144908
http://dx.doi.org/10.1371/journal.pgen.1002386

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228816/
https://www.ncbi.nlm.nih.gov/pubmed/22144908
http://dx.doi.org/10.1371/journal.pgen.1002386

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