Cargando…

Drug Discovery Toward Antagonists of Methyl-Lysine Binding Proteins

The recognition of methyl-lysine and -arginine residues on both histone and other proteins by specific “reader” elements is important for chromatin regulation, gene expression, and control of cell-cycle progression. Recently the crucial role of these reader proteins in cancer development and dediffe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herold, J. Martin, Ingerman, Lindsey A, Gao, Cen, Frye, Stephen V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bentham Open 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229088/ https://www.ncbi.nlm.nih.gov/pubmed/22145013 http://dx.doi.org/10.2174/1875397301005010051

Ejemplares similares

Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain
por: James, Lindsey I., et al.
Publicado: (2013)

Discovery of Potent Peptidomimetic Antagonists for Heterochromatin Protein 1 Family Proteins
por: Lamb, Kelsey N., et al.
Publicado: (2021)

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
por: Ma, Anqi, et al.
Publicado: (2014)

Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase
por: Talibov, Vladimir O., et al.
Publicado: (2021)

The functional diversity of protein lysine methylation
por: Lanouette, Sylvain, et al.
Publicado: (2014)

Intrinsic protein disorder in histone lysine methylation
por: Lazar, Tamas, et al.
Publicado: (2016)

Uncovering the Protein Lysine and Arginine Methylation Network in Arabidopsis Chloroplasts
por: Alban, Claude, et al.
Publicado: (2014)

Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery
por: Das, Nando Dulal, et al.
Publicado: (2023)

Cadaverine Production From L-Lysine With Chitin-Binding Protein-Mediated Lysine Decarboxylase Immobilization
por: Zhou, Ning, et al.
Publicado: (2020)

Toward the Discovery of Vaccine Adjuvants: Coupling In Silico Screening and In Vitro Analysis of Antagonist Binding to Human and Mouse CCR4 Receptors
por: Davies, Matthew N., et al.
Publicado: (2009)

Investigation of the methylation of Numb by the SET8 protein lysine methyltransferase
por: Weirich, Sara, et al.
Publicado: (2015)

Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization
por: Walter, Thomas S., et al.
Publicado: (2006)

Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
por: Wang, Jiaxu, et al.
Publicado: (2018)

Discovery of 9,11-Seco-Cholesterol Derivatives as Novel FXR Antagonists
por: Zhou, Jia-Xu, et al.
Publicado: (2022)

Intriguing Origins of Protein Lysine Methylation: Influencing Cell Function Through Dynamic Methylation
por: Mezey, Natalie, et al.
Publicado: (2019)

The Gluopsins: Opsins without the Retinal Binding Lysine
por: Gühmann, Martin, et al.
Publicado: (2022)

Histone Lysine Methylation in Diabetic Nephropathy
por: Sun, Guang-dong, et al.
Publicado: (2014)

Lysine methylation of transcription factors in cancer
por: Han, Dong, et al.
Publicado: (2019)

Histone Lysine Methylation and Neurodevelopmental Disorders
por: Kim, Jeong-Hoon, et al.
Publicado: (2017)

A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2
por: Horton, John R., et al.
Publicado: (2022)

Mechanistic basis of the increased methylation activity of the SETD2 protein lysine methyltransferase towards a designed super-substrate peptide
por: Schnee, Philipp, et al.
Publicado: (2022)

Site-selective lysine conjugation methods and applications towards antibody–drug conjugates
por: Haque, Muhammed, et al.
Publicado: (2021)

Towards reproducible computational drug discovery
por: Schaduangrat, Nalini, et al.
Publicado: (2020)

Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes
por: Pasini, Diego, et al.
Publicado: (2010)

Drug discovery for heart failure targeting myosin-binding protein C
por: Bunch, Thomas A., et al.
Publicado: (2023)

Understanding the relationship between DNA methylation and histone lysine methylation()
por: Rose, Nathan R., et al.
Publicado: (2014)

Methylation of Histone H3 on Lysine 4 by the Lysine Methyltransferase SET1 Protein Is Needed for Normal Clock Gene Expression
por: Raduwan, Hamidah, et al.
Publicado: (2013)

An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering
por: Cui, Gaofeng, et al.
Publicado: (2023)

Beta adrenergic antagonists and antianginal drugs
por: Stever, Lindsey M., et al.
Publicado: (2021)

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice
por: Fusser, Markus, et al.
Publicado: (2015)

Widespread occurrence of lysine methylation in Plasmodium falciparum proteins at asexual blood stages
por: Kaur, Inderjeet, et al.
Publicado: (2016)

Identification of protein lysine methylation readers with a yeast three-hybrid approach
por: Rawłuszko-Wieczorek, Agnieszka Anna, et al.
Publicado: (2018)

Lysine Methylation Modulates the Interaction of Archaeal Chromatin Protein Cren7 With DNA
por: Ding, Niannian, et al.
Publicado: (2022)

Writing, erasing and reading histone lysine methylations
por: Hyun, Kwangbeom, et al.
Publicado: (2017)

Chemical tools targeting readers of lysine methylation
por: Ortiz, Gloria, et al.
Publicado: (2023)

Author Correction: Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR
por: Wang, Jiaxu, et al.
Publicado: (2019)

Correction to ‘Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes’
por: Pasini, Diego, et al.
Publicado: (2021)

Biophysical Approaches Facilitate Computational Drug Discovery for ATP-Binding Cassette Proteins
por: Molinski, Steven V., et al.
Publicado: (2017)

Sumoylation of Cas9 at lysine 848 regulates protein stability and DNA binding
por: Ergünay, Tunahan, et al.
Publicado: (2022)

STING modulators: Predictive significance in drug discovery
por: Cui, Xiangling, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_1d7cuera0s6qpgojmhet4rnp9t