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A Computational Investigation of Cardiac Caveolae as a Source of Persistent Sodium Current

Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that caveolae are reservoirs of “recruitable” sodium ion channels. Caveolar channels constitute a substantial and previously unrecognized source of sodium current in cardiac cells. In this paper we model for the first...

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Detalles Bibliográficos
Autores principales: Besse, Ian M., Mitchell, Colleen C., Hund, Thomas J., Shibata, Erwin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229093/
https://www.ncbi.nlm.nih.gov/pubmed/22144962
http://dx.doi.org/10.3389/fphys.2011.00087