Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphim...

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Detalles Bibliográficos
Autores principales: Ponder, Jessica, Yoo, Byong Hoon, Abraham, Adedoyin D., Li, Qun, Ashley, Amanda K., Amerin, Courtney L., Zhou, Qiong, Reid, Brian G., Reigan, Philip, Hromas, Robert, Nickoloff, Jac A., LaBarbera, Daniel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229241/
https://www.ncbi.nlm.nih.gov/pubmed/22163192
http://dx.doi.org/10.3390/md9112397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229241/
https://www.ncbi.nlm.nih.gov/pubmed/22163192
http://dx.doi.org/10.3390/md9112397

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