The GATA1-HS2 Enhancer Allows Persistent and Position-Independent Expression of a β-globin Transgene

Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the...

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Detalles Bibliográficos
Autores principales: Miccio, Annarita, Poletti, Valentina, Tiboni, Francesca, Rossi, Claudia, Antonelli, Antonella, Mavilio, Fulvio, Ferrari, Giuliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229501/
https://www.ncbi.nlm.nih.gov/pubmed/22164220
http://dx.doi.org/10.1371/journal.pone.0027955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229501/
https://www.ncbi.nlm.nih.gov/pubmed/22164220
http://dx.doi.org/10.1371/journal.pone.0027955

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