Both hMutSα and hMutSß DNA Mismatch Repair Complexes Participate in 5-Fluorouracil Cytotoxicity

BACKGROUND: Patients with advanced microsatellite unstable colorectal cancers do not show a survival benefit from 5-fluorouracil (5-FU)-based chemotherapy. We and others have shown that the DNA mismatch repair (MMR) complex hMutSα binds 5-FU incorporated into DNA. Although hMutSß is known to interac...

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Detalles Bibliográficos
Autores principales: Tajima, Akihiro, Iwaizumi, Moriya, Tseng-Rogenski, Stephanie, Cabrera, Betty L., Carethers, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229514/
https://www.ncbi.nlm.nih.gov/pubmed/22164234
http://dx.doi.org/10.1371/journal.pone.0028117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229514/
https://www.ncbi.nlm.nih.gov/pubmed/22164234
http://dx.doi.org/10.1371/journal.pone.0028117

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