Constitutive MAP Kinase Activation in Hematopoietic Stem Cells Induces a Myeloproliferative Disorder

Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPNs) are a group of myeloid neoplasms in which abnormal activation of the Ras signaling pathway is commonly observed. The PI3K/Akt pathway is a known target of Ras; however, activation of the PI3K/Akt pathway has been shown to lead to neop...

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Detalles Bibliográficos
Autores principales: Chung, Eva, Hsu, Chia-Lin, Kondo, Motonari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229546/
https://www.ncbi.nlm.nih.gov/pubmed/22164275
http://dx.doi.org/10.1371/journal.pone.0028350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229546/
https://www.ncbi.nlm.nih.gov/pubmed/22164275
http://dx.doi.org/10.1371/journal.pone.0028350

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