Neighborhood Properties Are Important Determinants of Temperature Sensitive Mutations

Temperature-sensitive (TS) mutants are powerful tools to study gene function in vivo. These mutants exhibit wild-type activity at permissive temperatures and reduced activity at restrictive temperatures. Although random mutagenesis can be used to generate TS mutants, the procedure is laborious and u...

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Detalles Bibliográficos
Autores principales: Lockwood, Svetlana, Krishnamoorthy, Bala, Ye, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229608/
https://www.ncbi.nlm.nih.gov/pubmed/22164302
http://dx.doi.org/10.1371/journal.pone.0028507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229608/
https://www.ncbi.nlm.nih.gov/pubmed/22164302
http://dx.doi.org/10.1371/journal.pone.0028507

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