Cargando…

Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis

AIMS: A defective DNA damage response can result in genomic instability (GIN) and lead to transformation to cancer. As p53-binding protein 1 (53BP1) localizes at the sites of DNA double strand breaks (DSBs) and rapidly forms nuclear foci (NF), the presence of 53BP1 NF can be considered to be an indi...

Descripción completa

Detalles Bibliográficos
Autores principales: Matsuda, Katsuya, Miura, Shiro, Kurashige, Tomomi, Suzuki, Keiji, Kondo, Hisayoshi, Ihara, Makoto, Nakajima, Hisayoshi, Masuzaki, Hideaki, Nakashima, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229684/
https://www.ncbi.nlm.nih.gov/pubmed/22034884
http://dx.doi.org/10.1111/j.1365-2559.2011.03963.x