Coping with time scales in disease systems analysis: application to bone remodeling

In this study we demonstrate the added value of mathematical model reduction for characterizing complex dynamic systems using bone remodeling as an example. We show that for the given parameter values, the mechanistic RANK-RANKL-OPG pathway model proposed by Lemaire et al. (J Theor Biol 229:293–309,...

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Detalles Bibliográficos
Autores principales: Schmidt, Stephan, Post, Teun M., Peletier, Lambertus A., Boroujerdi, Massoud A., Danhof, Meindert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230316/
https://www.ncbi.nlm.nih.gov/pubmed/22028207
http://dx.doi.org/10.1007/s10928-011-9224-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230316/
https://www.ncbi.nlm.nih.gov/pubmed/22028207
http://dx.doi.org/10.1007/s10928-011-9224-2

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