Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process

BACKGROUND: The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS) process. METHODS: First, excipients for enhancing the stability and sol...

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Detalles Bibliográficos
Autores principales: Kim, Min-Soo, Kim, Jeong-Soo, Park, Hee Jun, Cho, Won Kyung, Cha, Kwang-Ho, Hwang, Sung-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230567/
https://www.ncbi.nlm.nih.gov/pubmed/22162657
http://dx.doi.org/10.2147/IJN.S26546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230567/
https://www.ncbi.nlm.nih.gov/pubmed/22162657
http://dx.doi.org/10.2147/IJN.S26546

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