Concanavalin A/IFN-Gamma Triggers Autophagy-Related Necrotic Hepatocyte Death through IRGM1-Mediated Lysosomal Membrane Disruption

Interferon-gamma (IFN-γ), a potent Th1 cytokine with multiple biological functions, can induce autophagy to enhance the clearance of the invading microorganism or cause cell death. We have reported that Concanavalin A (Con A) can cause autophagic cell death in hepatocytes and induce both T cell-depe...

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Detalles Bibliográficos
Autores principales: Chang, Chih-Peng, Yang, Ming-Chen, Lei, Huan-Yao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230628/
https://www.ncbi.nlm.nih.gov/pubmed/22163006
http://dx.doi.org/10.1371/journal.pone.0028323

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230628/
https://www.ncbi.nlm.nih.gov/pubmed/22163006
http://dx.doi.org/10.1371/journal.pone.0028323

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