Mechanistic Insights into the Activation of Oncogenic Forms of EGF Receptor

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly activated by mutation in non-small cell lung cancer. The mechanism of this oncogenic activation is incompletely understood but, in contrast to the WT EGFR, is proposed to be independent of kinase domain dimerizati...

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Detalles Bibliográficos
Autores principales: Wang, Zhihong, Longo, Patti A., Tarrant, Mary Katherine, Kim, Kwangsoo, Head, Sarah, Leahy, Daniel J., Cole, Philip A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230693/
https://www.ncbi.nlm.nih.gov/pubmed/22101934
http://dx.doi.org/10.1038/nsmb.2168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3230693/
https://www.ncbi.nlm.nih.gov/pubmed/22101934
http://dx.doi.org/10.1038/nsmb.2168

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