Talampanel reduces the level of motoneuronal calcium in transgenic mutant SOD1 mice only if applied presymptomatically

We tested the efficacy of treatment with talampanel in a mutant SOD1 mouse model of ALS by measuring intracellular calcium levels and loss of spinal motor neurons. We intended to mimic the clinical study; hence, treatment was started when the clinical symptoms were already present. The data were com...

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Detalles Bibliográficos
Autores principales: Paizs, Melinda, Tortarolo, Massimo, Bendotti, Caterina, Engelhardt, Jozsef I, Siklós, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2011
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231880/
https://www.ncbi.nlm.nih.gov/pubmed/21623665
http://dx.doi.org/10.3109/17482968.2011.584627

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231880/
https://www.ncbi.nlm.nih.gov/pubmed/21623665
http://dx.doi.org/10.3109/17482968.2011.584627

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