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Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again

Before a probiotic bacterium can even begin to fulfill its biological role, it must survive a battery of environmental stresses imposed during food processing and passage through the gastrointestinal tract (GIT). Food processing stresses include extremes in temperature, as well as osmotic, oxidative...

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Detalles Bibliográficos
Autores principales: Mills, Susan, Stanton, Catherine, Fitzgerald, Gerald F, Ross, R Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231925/
https://www.ncbi.nlm.nih.gov/pubmed/21995734
http://dx.doi.org/10.1186/1475-2859-10-S1-S19
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author Mills, Susan
Stanton, Catherine
Fitzgerald, Gerald F
Ross, R Paul
author_facet Mills, Susan
Stanton, Catherine
Fitzgerald, Gerald F
Ross, R Paul
author_sort Mills, Susan
collection PubMed
description Before a probiotic bacterium can even begin to fulfill its biological role, it must survive a battery of environmental stresses imposed during food processing and passage through the gastrointestinal tract (GIT). Food processing stresses include extremes in temperature, as well as osmotic, oxidative and food matrix stresses. Passage through the GIT is a hazardous journey for any bacteria with deleterious lows in pH encountered in the stomach to the detergent-like properties of bile in the duodenum. However, bacteria are equipped with an array of defense mechanisms to counteract intracellular damage or to enhance the robustness of the cell to withstand lethal external environments. Understanding these mechanisms in probiotic bacteria and indeed other bacterial groups has resulted in the development of a molecular toolbox to augment the technological and gastrointestinal performance of probiotics. This has been greatly aided by studies which examine the global cellular responses to stress highlighting distinct regulatory networks and which also identify novel mechanisms used by cells to cope with hazardous environments. This review highlights the latest studies which have exploited the bacterial stress response with a view to producing next-generation probiotic cultures and highlights the significance of studies which view the global bacterial stress response from an integrative systems biology perspective.
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spelling pubmed-32319252011-12-07 Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again Mills, Susan Stanton, Catherine Fitzgerald, Gerald F Ross, R Paul Microb Cell Fact Proceedings Before a probiotic bacterium can even begin to fulfill its biological role, it must survive a battery of environmental stresses imposed during food processing and passage through the gastrointestinal tract (GIT). Food processing stresses include extremes in temperature, as well as osmotic, oxidative and food matrix stresses. Passage through the GIT is a hazardous journey for any bacteria with deleterious lows in pH encountered in the stomach to the detergent-like properties of bile in the duodenum. However, bacteria are equipped with an array of defense mechanisms to counteract intracellular damage or to enhance the robustness of the cell to withstand lethal external environments. Understanding these mechanisms in probiotic bacteria and indeed other bacterial groups has resulted in the development of a molecular toolbox to augment the technological and gastrointestinal performance of probiotics. This has been greatly aided by studies which examine the global cellular responses to stress highlighting distinct regulatory networks and which also identify novel mechanisms used by cells to cope with hazardous environments. This review highlights the latest studies which have exploited the bacterial stress response with a view to producing next-generation probiotic cultures and highlights the significance of studies which view the global bacterial stress response from an integrative systems biology perspective. BioMed Central 2011-08-30 /pmc/articles/PMC3231925/ /pubmed/21995734 http://dx.doi.org/10.1186/1475-2859-10-S1-S19 Text en Copyright ©2011 Mills et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Proceedings
Mills, Susan
Stanton, Catherine
Fitzgerald, Gerald F
Ross, R Paul
Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
title Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
title_full Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
title_fullStr Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
title_full_unstemmed Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
title_short Enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
title_sort enhancing the stress responses of probiotics for a lifestyle from gut to product and back again
topic Proceedings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231925/
https://www.ncbi.nlm.nih.gov/pubmed/21995734
http://dx.doi.org/10.1186/1475-2859-10-S1-S19
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