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Role and expression of FRS2 and FRS3 in prostate cancer

BACKGROUND: FGF receptor substrates (FRS2 and FRS3) are key adaptor proteins that mediate FGF-FGFR signalling in benign as well as malignant tissue. Here we investigated FRS2 and FRS3 as a means of disrupting global FGF signalling in prostate cancer. METHODS: FRS2 and FRS3 manipulation was investiga...

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Detalles Bibliográficos
Autores principales: Valencia, Tania, Joseph, Ajay, Kachroo, Naveen, Darby, Steve, Meakin, Susan, Gnanapragasam, Vincent J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231952/
https://www.ncbi.nlm.nih.gov/pubmed/22078327
http://dx.doi.org/10.1186/1471-2407-11-484