The Case of the Fickle Fingers: How the PRDM9 Zinc Finger Protein Specifies Meiotic Recombination Hotspots in Humans

During mammalian meiosis, double-strand breaks are deliberately made throughout the genome and then repaired, leading to the exchange of genetic material between copies of chromosomes. How the locations of breaks are specified was largely unknown until a fortuitous confluence of statistical genetics...

Descripción completa

Detalles Bibliográficos
Autores principales: Ségurel, Laure, Leffler, Ellen Miranda, Przeworski, Molly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Unsolved Mystery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232208/
https://www.ncbi.nlm.nih.gov/pubmed/22162947
http://dx.doi.org/10.1371/journal.pbio.1001211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232208/
https://www.ncbi.nlm.nih.gov/pubmed/22162947
http://dx.doi.org/10.1371/journal.pbio.1001211

Ejemplares similares