MicroRNA-1 and -133 Increase Arrhythmogenesis in Heart Failure by Dissociating Phosphatase Activity from RyR2 Complex

In heart failure (HF), arrhythmogenic spontaneous sarcoplasmic reticulum (SR) Ca(2+) release and afterdepolarizations in cardiac myocytes have been linked to abnormally high activity of ryanodine receptors (RyR2s) associated with enhanced phosphorylation of the channel. However, the specific molecul...

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Detalles Bibliográficos
Autores principales: Belevych, Andriy E., Sansom, Sarah E., Terentyeva, Radmila, Ho, Hsiang-Ting, Nishijima, Yoshinori, Martin, Mickey M., Jindal, Hitesh K., Rochira, Jennifer A., Kunitomo, Yukiko, Abdellatif, Maha, Carnes, Cynthia A., Elton, Terry S., Györke, Sandor, Terentyev, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232211/
https://www.ncbi.nlm.nih.gov/pubmed/22163007
http://dx.doi.org/10.1371/journal.pone.0028324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232211/
https://www.ncbi.nlm.nih.gov/pubmed/22163007
http://dx.doi.org/10.1371/journal.pone.0028324

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