Correlation of Inter-Locus Polyglutamine Toxicity with CAG•CTG Triplet Repeat Expandability and Flanking Genomic DNA GC Content

Dynamic expansions of toxic polyglutamine (polyQ)-encoding CAG repeats in ubiquitously expressed, but otherwise unrelated, genes cause a number of late-onset progressive neurodegenerative disorders, including Huntington disease and the spinocerebellar ataxias. As polyQ toxicity in these disorders in...

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Detalles Bibliográficos
Autores principales: Nestor, Colm E., Monckton, Darren G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232215/
https://www.ncbi.nlm.nih.gov/pubmed/22163004
http://dx.doi.org/10.1371/journal.pone.0028260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232215/
https://www.ncbi.nlm.nih.gov/pubmed/22163004
http://dx.doi.org/10.1371/journal.pone.0028260

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