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Nifedipine Protects INS-1 β-Cell from High Glucose-Induced ER Stress and Apoptosis
Sustained high concentration of glucose has been verified toxic to β-cells. Glucose augments Ca(2+)-stimulated insulin release in pancreatic β-cells, but chronic high concentration of glucose could induce a sustained level of Ca(2+) in β-cells, which leads to cell apoptosis. However, the mechanism o...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Molecular Diversity Preservation International (MDPI)
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233423/ https://www.ncbi.nlm.nih.gov/pubmed/22174617 http://dx.doi.org/10.3390/ijms12117569 |