Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo

We demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also ind...

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Detalles Bibliográficos
Autores principales: Hong, Dae Young, Kwon, Kisang, Lee, Kyeong Ryong, Choi, Young Jin, Goo, Tae-Won, Yu, Kweon, Kim, Seung-Whan, Kwon, O-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233429/
https://www.ncbi.nlm.nih.gov/pubmed/22174623
http://dx.doi.org/10.3390/ijms12117652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233429/
https://www.ncbi.nlm.nih.gov/pubmed/22174623
http://dx.doi.org/10.3390/ijms12117652

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