Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis

The evolution of colorectal cancer suggests the involvement of many genes. We performed insertional mutagenesis with the Sleeping Beauty (SB) transposon system in mice carrying germline or somatic Apc mutation. Analysis of common insertion sites (CISs) isolated from 446 tumors revealed many hundreds...

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Detalles Bibliográficos
Autores principales: March, H. Nikki, Rust, Alistair G., Wright, Nicholas A., Hoeve, Jelle ten, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J., Wessels, Lodewyk F. A., Winton, Douglas J., Adams, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233530/
https://www.ncbi.nlm.nih.gov/pubmed/22057237
http://dx.doi.org/10.1038/ng.990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233530/
https://www.ncbi.nlm.nih.gov/pubmed/22057237
http://dx.doi.org/10.1038/ng.990

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