Cargando…

Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis

The evolution of colorectal cancer suggests the involvement of many genes. We performed insertional mutagenesis with the Sleeping Beauty (SB) transposon system in mice carrying germline or somatic Apc mutation. Analysis of common insertion sites (CISs) isolated from 446 tumors revealed many hundreds...

Descripción completa

Detalles Bibliográficos
Autores principales:	March, H. Nikki, Rust, Alistair G., Wright, Nicholas A., Hoeve, Jelle ten, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J., Wessels, Lodewyk F. A., Winton, Douglas J., Adams, David J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233530/ https://www.ncbi.nlm.nih.gov/pubmed/22057237 http://dx.doi.org/10.1038/ng.990

Ejemplares similares

Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens
por: de Ridder, Jeroen, et al.
Publicado: (2006)

Computational identification of insertional mutagenesis targets for cancer gene discovery
por: de Jong, Johann, et al.
Publicado: (2011)

Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance
por: Ikink, Gerjon J., et al.
Publicado: (2018)

Increased tumorigenesis associated with loss of the tumor suppressor gene Cadm1
por: van der Weyden, Louise, et al.
Publicado: (2012)

RUBIC identifies driver genes by detecting recurrent DNA copy number breaks
por: van Dyk, Ewald, et al.
Publicado: (2016)

Large-Scale Mutagenesis in p19(ARF)- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks
por: Uren, Anthony G., et al.
Publicado: (2008)

Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis
por: Huser, Camille A., et al.
Publicado: (2014)

Chromatin Landscapes of Retroviral and Transposon Integration Profiles
por: de Jong, Johann, et al.
Publicado: (2014)

Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAF(V600E)-Driven Lung Tumorigenesis
por: Vaishnavi, Aria, et al.
Publicado: (2022)

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation
por: Wilson, Catherine H, et al.
Publicado: (2012)

Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets
por: Farazi, Thalia A, et al.
Publicado: (2014)

Acute sensitivity of the oral mucosa to oncogenic K-ras
por: van der Weyden, Louise, et al.
Publicado: (2011)

Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas
por: Dawes, Joanna C., et al.
Publicado: (2021)

Turning off the BCL-2 switch to prevent intestinal tumorigenesis
por: van der Heijden, Maartje, et al.
Publicado: (2016)

Inhibitory effect of Actinidia arguta on mutagenesis, inflammation and two-stage mouse skin tumorigenesis
por: Nishimura, Mari, et al.
Publicado: (2016)

Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors
por: Klijn, Christiaan, et al.
Publicado: (2013)

Generation of the Sotos syndrome deletion in mice
por: Migdalska, Anna M., et al.
Publicado: (2012)

Insertional mutagenesis strategies in zebrafish
por: Sivasubbu, Sridhar, et al.
Publicado: (2007)

Synchronous BRAF(V600E) and MEK inhibition leads to superior control of murine melanoma by limiting MEK inhibitor induced skin toxicity
por: Gadiot, Jules, et al.
Publicado: (2013)

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
por: Pérez-Mancera, Pedro A., et al.
Publicado: (2012)

Inferring combinatorial association logic networks in multimodal genome-wide screens
por: de Ridder, Jeroen, et al.
Publicado: (2010)

Long-Distance Effects of Insertional Mutagenesis
por: Singhal, Ruchi, et al.
Publicado: (2011)

Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data
por: Klijn, Christiaan, et al.
Publicado: (2008)

Identification of cancer genes using a statistical framework for multi-experiment analysis of non-discretized array CGH data
por: Klijn, Christiaan, et al.
Publicado: (2008)

Applications of DNA integrating elements: Facing the bias bully
por: de Jong, Johann, et al.
Publicado: (2015)

Selective BRAF inhibition decreases tumor-resident lymphocyte frequencies in a mouse model of human melanoma
por: Hooijkaas, Anna, et al.
Publicado: (2012)

Inactivating CUX1 mutations promote tumorigenesis
por: Wong, Chi C., et al.
Publicado: (2013)

Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5(+/−) leukemia
por: van der Weyden, Louise, et al.
Publicado: (2015)

Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae
por: Filcek, Kimberly, et al.
Publicado: (2019)

Targeted insertional mutagenesis libraries for deep domain insertion profiling
por: Coyote-Maestas, Willow, et al.
Publicado: (2020)

Targeted insertional mutagenesis libraries for deep domain insertion profiling
por: Coyote-Maestas, Willow, et al.
Publicado: (2020)

CRISPR-Cas9-Mediated Mutagenesis of the Rubisco Small Subunit Family in Nicotiana tabacum
por: Donovan, Sophie, et al.
Publicado: (2020)

GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors
por: Westerman, Bart A., et al.
Publicado: (2012)

From Chemical Mutagenesis to Post‐Expression Mutagenesis: A 50 Year Odyssey
por: Wright, Tom H., et al.
Publicado: (2016)

Germline Transgenesis and Insertional Mutagenesis in Schistosoma mansoni Mediated by Murine Leukemia Virus
por: Rinaldi, Gabriel, et al.
Publicado: (2012)

Generation of an Enhancer-Trapping Vector for Insertional Mutagenesis in Zebrafish
por: Liu, Chunyan, et al.
Publicado: (2015)

Insertional Mutagenesis Approaches and Their Use in Rice for Functional Genomics
por: Ram, Hasthi, et al.
Publicado: (2019)

Inferring the Minimal Genome of Mesoplasma florum by Comparative Genomics and Transposon Mutagenesis
por: Baby, Vincent, et al.
Publicado: (2018)

Identifying transposon insertions and their effects from RNA-sequencing data
por: de Ruiter, Julian R., et al.
Publicado: (2017)

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
por: Zhang, Yihong, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_d60f0onkkcf41t2i6mt8f3snfb