Protein 3D Structure Computed from Evolutionary Sequence Variation

The evolutionary trajectory of a protein through sequence space is constrained by its function. Collections of sequence homologs record the outcomes of millions of evolutionary experiments in which the protein evolves according to these constraints. Deciphering the evolutionary record held in these...

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Detalles Bibliográficos
Autores principales: Marks, Debora S., Colwell, Lucy J., Sheridan, Robert, Hopf, Thomas A., Pagnani, Andrea, Zecchina, Riccardo, Sander, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233603/
https://www.ncbi.nlm.nih.gov/pubmed/22163331
http://dx.doi.org/10.1371/journal.pone.0028766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3233603/
https://www.ncbi.nlm.nih.gov/pubmed/22163331
http://dx.doi.org/10.1371/journal.pone.0028766

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