The dose can make the poison: lessons learned from adverse in vivo toxicities caused by RNAi overexpression

For the past five years, evidence has accumulated that vector-mediated robust RNA interference (RNAi) expression can trigger severe side effects in small and large animals, from cytotoxicity and accelerated tumorigenesis to organ failure and death. The recurring notions in these studies that a criti...

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Detalles Bibliográficos
Autor principal: Grimm, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234190/
https://www.ncbi.nlm.nih.gov/pubmed/22029761
http://dx.doi.org/10.1186/1758-907X-2-8