Cargando…

Structural Insights into the Inhibition of Cytosolic 5′-Nucleotidase II (cN-II) by Ribonucleoside 5′-Monophosphate Analogues

Cytosolic 5′-nucleotidase II (cN-II) regulates the intracellular nucleotide pools within the cell by catalyzing the dephosphorylation of 6-hydroxypurine nucleoside 5′-monophosphates. Beside this physiological function, high level of cN-II expression is correlated with abnormal patient outcome when t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gallier, Franck, Lallemand, Perrine, Meurillon, Maïa, Jordheim, Lars P., Dumontet, Charles, Périgaud, Christian, Lionne, Corinne, Peyrottes, Suzanne, Chaloin, Laurent
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234209/ https://www.ncbi.nlm.nih.gov/pubmed/22174667 http://dx.doi.org/10.1371/journal.pcbi.1002295

Ejemplares similares

Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation
por: Nguyen Van, Tai, et al.
Publicado: (2016)

Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface
por: Rahimova, Rahila, et al.
Publicado: (2018)

The cytosolic 5′-nucleotidase cN-II lowers the adaptability to glucose deprivation in human breast cancer cells
por: Bricard, Gabriel, et al.
Publicado: (2017)

Cytosolic 5’-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf
por: Cividini, Federico, et al.
Publicado: (2015)

Recent advances in structure and function of cytosolic IMP-GMP specific 5′nucleotidase II (cN-II)
por: Ipata, Piero Luigi, et al.
Publicado: (2006)

Expression of Bovine Cytosolic 5′-Nucleotidase (cN-II) in Yeast: Nucleotide Pools Disturbance and Its Consequences on Growth and Homologous Recombination
por: Allegrini, Simone, et al.
Publicado: (2013)

Cytosolic 5′-Nucleotidase II Is a Sensor of Energy Charge and Oxidative Stress: A Possible Function as Metabolic Regulator
por: Pesi, Rossana, et al.
Publicado: (2021)

Cytosolic 5′-Nucleotidase II Silencing in Lung Tumor Cells Regulates Metabolism through Activation of the p53/AMPK Signaling Pathway
por: Pesi, Rossana, et al.
Publicado: (2021)

A role for Rad5 in ribonucleoside monophosphate (rNMP) tolerance
por: Elserafy, Menattallah, et al.
Publicado: (2021)

Synthesis of (R)- and (S)-β-hydroxyphosphonate acyclonucleosides: structural analogues of Adefovir (PMEA)
por: Kasthuri, Mahesh, et al.
Publicado: (2011)

Cytosolic 5′-Nucleotidase II Silencing in a Human Lung Carcinoma Cell Line Opposes Cancer Phenotype with a Concomitant Increase in p53 Phosphorylation
por: Pesi, Rossana, et al.
Publicado: (2018)

5'-nucleotidase cN-II emerges as a new predictive biomarker of response to gemcitabine/platinum combination chemotherapy in non-small cell lung cancer
por: Toffalorio, Francesca, et al.
Publicado: (2018)

Transcriptional and Metabolic Investigation in 5′-Nucleotidase Deficient Cancer Cell Lines
por: Cadassou, Octavia, et al.
Publicado: (2021)

Investigating cytosolic 5′-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr)
por: Singgih, Euginia L., et al.
Publicado: (2021)

Anti–Cytosolic 5′‐Nucleotidase 1A Autoantibodies Are Absent in Juvenile Dermatomyositis
por: Rietveld, Anke, et al.
Publicado: (2021)

Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase
por: Gondeau, C., et al.
Publicado: (2008)

Autoantibodies to Cytosolic 5′-Nucleotidase 1A in Primary Sjögren’s Syndrome and Systemic Lupus Erythematosus
por: Rietveld, Anke, et al.
Publicado: (2018)

Cytosolic 5′-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis
por: Lilleker, J B, et al.
Publicado: (2017)

Evidence for a Cross-Talk Between Cytosolic 5′-Nucleotidases and AMP-Activated Protein Kinase
por: Camici, Marcella, et al.
Publicado: (2020)

Clinical utility of anti‐cytosolic 5’‐nucleotidase 1A antibody in idiopathic inflammatory myopathies
por: Ikenaga, Chiseko, et al.
Publicado: (2021)

Targeted deletion of ecto-5′-nucleotidase results in retention of inosine monophosphate content in postmortem muscle of medaka (Oryzias latipes)
por: Murakami, Yu, et al.
Publicado: (2022)

5'-Nucleotidase activity of mouse peritoneal macrophages. II. Cellular distribution and effects of endocytosis
Publicado: (1976)

Crystal Structures of the Novel Cytosolic 5′-Nucleotidase IIIB Explain Its Preference for m(7)GMP
por: Monecke, Thomas, et al.
Publicado: (2014)

Localization of putative binding sites for cyclic guanosine monophosphate and the anti-cancer drug 5-fluoro-2′-deoxyuridine-5′-monophosphate on ABCC11 in silico models
por: Honorat, Mylène, et al.
Publicado: (2013)

About Pyrimidine 5’-Nucleotidase Deficiency
por: Özsoylu, Şinasi
Publicado: (2013)

Effect of two non-synonymous ecto-5′-nucleotidase variants on the genetic architecture of inosine 5′-monophosphate (IMP) and its degradation products in Japanese Black beef
por: Uemoto, Yoshinobu, et al.
Publicado: (2017)

Transient kinetics of aminoglycoside phosphotransferase(3′)-IIIa reveals a potential drug target in the antibiotic resistance mechanism
por: Lallemand, Perrine, et al.
Publicado: (2012)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
por: Patzak, Melanie S., et al.
Publicado: (2019)

Ecto-5’-nucleotidase: Structure function relationships
por: Sträter, Norbert
Publicado: (2006)

Intracellular Distribution of 5' Nucleotidase in Rat Liver
por: de Lamirande, Gaston, et al.
Publicado: (1958)

CYTOCHEMICAL LOCALIZATION OF 5'-NUCLEOTIDASE IN SUBCELLULAR FRACTIONS ISOLATED FROM RAT LIVER : I. The Origin of 5'-Nucleotidase Activity in Microsomes
por: Widnell, Christopher C.
Publicado: (1972)

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism
por: Kubacka, Dorota, et al.
Publicado: (2022)

Physiological roles for ecto-5’-nucleotidase (CD73)
por: Colgan, Sean P., et al.
Publicado: (2006)

Choline Analogues in Malaria Chemotherapy
por: Peyrottes, Suzanne, et al.
Publicado: (2012)

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides
por: Arnold, Jamie J., et al.
Publicado: (2012)

Overexpression of Inosine 5′-Monophosphate Dehydrogenase Type II Mediates Chemoresistance to Human Osteosarcoma Cells
por: Fellenberg, Jörg, et al.
Publicado: (2010)

Naturally occurring modified ribonucleosides
por: McCown, Phillip J., et al.
Publicado: (2020)

Bacillus subtilis 5′-nucleotidases with various functions and substrate specificities
por: Terakawa, Ayako, et al.
Publicado: (2016)

Analgesia with 5' extracellular nucleotidase-mediated electroacupuncture for neuropathic pain
por: Dai, Qin-xue, et al.
Publicado: (2022)

Novel microRNAs modulating ecto-5′-nucleotidase expression
por: Kordaß, Theresa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3ah1oumph0eh5dbr9rn30l2486