The FGFR4-G388R Polymorphism Promotes Mitochondrial STAT3 Serine Phosphorylation to Facilitate Pituitary Growth Hormone Cell Tumorigenesis

Pituitary tumors are common intracranial neoplasms, yet few germline abnormalities have been implicated in their pathogenesis. Here we show that a single nucleotide germline polymorphism (SNP) substituting an arginine (R) for glycine (G) in the FGFR4 transmembrane domain can alter pituitary cell gro...

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Detalles Bibliográficos
Autores principales: Tateno, Toru, Asa, Sylvia L., Zheng, Lei, Mayr, Thomas, Ullrich, Axel, Ezzat, Shereen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234213/
https://www.ncbi.nlm.nih.gov/pubmed/22174695
http://dx.doi.org/10.1371/journal.pgen.1002400

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234213/
https://www.ncbi.nlm.nih.gov/pubmed/22174695
http://dx.doi.org/10.1371/journal.pgen.1002400

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