Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

Neuronal degeneration is a hallmark of many DNA repair syndromes. Yet, how DNA damage causes neuronal degeneration and whether defects in different repair systems affect the brain differently is largely unknown. Here, we performed a systematic detailed analysis of neurodegenerative changes in mouse...

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Detalles Bibliográficos
Autores principales: Jaarsma, Dick, van der Pluijm, Ingrid, de Waard, Monique C., Haasdijk, Elize D., Brandt, Renata, Vermeij, Marcel, Rijksen, Yvonne, Maas, Alex, van Steeg, Harry, Hoeijmakers, Jan H. J., van der Horst, Gijsbertus T. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234220/
https://www.ncbi.nlm.nih.gov/pubmed/22174697
http://dx.doi.org/10.1371/journal.pgen.1002405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234220/
https://www.ncbi.nlm.nih.gov/pubmed/22174697
http://dx.doi.org/10.1371/journal.pgen.1002405

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