In Vitro Downregulation of Matrix Metalloproteinase-9 in Rat Glial Cells by CCR5 Antagonist Maraviroc: Therapeutic Implication for HIV Brain Infection

BACKGROUND: Matrix metalloproteinases (MMPs) released by glial cells are important mediators of neuroinflammation and neurologic damage in HIV infection. The use of antiretroviral drugs able to combat the detrimental effect of chronic inflammation and target the exaggerated MMP activity might repres...

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Detalles Bibliográficos
Autores principales: Gramegna, Pasqua, Latronico, Tiziana, Branà, Maria Teresa, Di Bari, Gaetano, Mengoni, Fabio, Belvisi, Valeria, Mascellino, Maria T., Lichtner, Miriam, Vullo, Vincenzo, Mastroianni, Claudio M., Liuzzi, Grazia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234279/
https://www.ncbi.nlm.nih.gov/pubmed/22174822
http://dx.doi.org/10.1371/journal.pone.0028499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234279/
https://www.ncbi.nlm.nih.gov/pubmed/22174822
http://dx.doi.org/10.1371/journal.pone.0028499

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