Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

Tumor necrosis factor α (TNFα) is a well known cytokine involved in systemic and acute inflammation. In this study, we demonstrate that ceramide 1-phosphate (C1P) produced by ceramide kinase (CERK) is a negative regulator of LPS-induced TNFα secretion. Specifically, bone marrow-derived macrophages i...

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Detalles Bibliográficos
Autores principales: Lamour, Nadia F., Wijesinghe, Dayanjan S., Mietla, Jennifer A., Ward, Katherine E., Stahelin, Robert V., Chalfant, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Lipids
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234830/
https://www.ncbi.nlm.nih.gov/pubmed/22009748
http://dx.doi.org/10.1074/jbc.M111.310169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3234830/
https://www.ncbi.nlm.nih.gov/pubmed/22009748
http://dx.doi.org/10.1074/jbc.M111.310169

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