Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome

Angelman syndrome (AS), a genetic disorder occurring in approximately one in every 15,000 births, is characterized by severe mental retardation, seizures, difficulty speaking and ataxia. The gene responsible for AS was discovered to be UBE3A and encodes for E6-AP, an ubiquitin ligase. A unique featu...

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Detalles Bibliográficos
Autores principales: Daily, Jennifer L., Nash, Kevin, Jinwal, Umesh, Golde, Todd, Rogers, Justin, Peters, Melinda M., Burdine, Rebecca D., Dickey, Chad, Banko, Jessica L., Weeber, Edwin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235088/
https://www.ncbi.nlm.nih.gov/pubmed/22174738
http://dx.doi.org/10.1371/journal.pone.0027221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235088/
https://www.ncbi.nlm.nih.gov/pubmed/22174738
http://dx.doi.org/10.1371/journal.pone.0027221

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