Diverging Mechanisms of Activation of Chemokine Receptors Revealed by Novel Chemokine Agonists

CXCL8/interleukin-8 is a pro-inflammatory chemokine that triggers pleiotropic responses, including inflammation, angiogenesis, wound healing and tumorigenesis. We engineered the first selective CXCR1 agonists on the basis of residue substitutions in the conserved ELR triad and CXC motif of CXCL8. Ou...

Descripción completa

Detalles Bibliográficos
Autores principales: Sarmiento, Jose, Shumate, Christie, Suetomi, Katsutoshi, Ravindran, Aishwarya, Villegas, León, Rajarathnam, Krishna, Navarro, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235101/
https://www.ncbi.nlm.nih.gov/pubmed/22174759
http://dx.doi.org/10.1371/journal.pone.0027967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235101/
https://www.ncbi.nlm.nih.gov/pubmed/22174759
http://dx.doi.org/10.1371/journal.pone.0027967

Ejemplares similares