Improved siRNA/shRNA Functionality by Mismatched Duplex

siRNA (small interfering RNA) and shRNA (small hairpin RNA) are powerful and commonly used tools in biomedical research. Currently, siRNAs are generally designed as two 21 nt strands of RNA that include a 19 nt completely complementary part and a 2 nt overhang. However, since the si/shRNAs use the e...

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Detalles Bibliográficos
Autores principales: Wu, Haoquan, Ma, Hongming, Ye, Chunting, Ramirez, Danielle, Chen, Shuiping, Montoya, Jessica, Shankar, Premlata, Wang, Xiaozhong A., Manjunath, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235145/
https://www.ncbi.nlm.nih.gov/pubmed/22174840
http://dx.doi.org/10.1371/journal.pone.0028580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235145/
https://www.ncbi.nlm.nih.gov/pubmed/22174840
http://dx.doi.org/10.1371/journal.pone.0028580

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