Adenoviral Vector Driven by a Minimal Rad51 Promoter Is Selective for p53-Deficient Tumor Cells

BACKGROUND: The full length Rad51 promoter is highly active in cancer cells but not in normal cells. We therefore set out to assess whether we could confer this tumor-selectivity to an adenovirus vector. METHODOLOGY/PRINCIPAL FINDINGS: Expression of an adenovirally-vectored luciferase reporter gene...

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Detalles Bibliográficos
Autores principales: Fong, Vincent, Osterbur, Marika, Capella, Cristina, Kim, Yo-El, Hine, Christopher, Gorbunova, Vera, Seluanov, Andrei, Dewhurst, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235156/
https://www.ncbi.nlm.nih.gov/pubmed/22174876
http://dx.doi.org/10.1371/journal.pone.0028714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235156/
https://www.ncbi.nlm.nih.gov/pubmed/22174876
http://dx.doi.org/10.1371/journal.pone.0028714

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