Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

The embryonic pyruvate kinase M2 (PKM2) isoform is highly expressed in human cancer. In contrast to the established role of PKM2 in aerobic glycolysis or the Warburg effect(1,2,3), its nonmetabolic functions remain elusive. Here we demonstrate that EGFR activation induces translocation of PKM2, but...

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Detalles Bibliográficos
Autores principales: Yang, Weiwei, Xia, Yan, Ji, Haitao, Zheng, Yanhua, Liang, Ji, Huang, Wenhua, Gao, Xiang, Aldape, Kenneth, Lu, Zhimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235705/
https://www.ncbi.nlm.nih.gov/pubmed/22056988
http://dx.doi.org/10.1038/nature10598

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235705/
https://www.ncbi.nlm.nih.gov/pubmed/22056988
http://dx.doi.org/10.1038/nature10598

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