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Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. The neoplasm occurred as a complication of radiot...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235721/ https://www.ncbi.nlm.nih.gov/pubmed/22203850 http://dx.doi.org/10.1155/2011/325193 |
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author | Kinra, Prateek Srinivas, V. Sinha, Kavita Dutta, Vibha |
author_facet | Kinra, Prateek Srinivas, V. Sinha, Kavita Dutta, Vibha |
author_sort | Kinra, Prateek |
collection | PubMed |
description | Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. The neoplasm occurred as a complication of radiotherapy (excessive cumulative radiation dose of 60 Gray) for carcinoma larynx with a latency period of three years. Postradiation spindle cell carcinoma is an uncommon disease manifesting as sarcoma in a previously irradiated field, usually with a latent period of 5 years or more. Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. The two components of the tumour were confirmed using the immunohistochemical staining (cytokeratin and vimentin). Further p53 positivity of the sarcomatous elements aided in ruling out radiation-induced nonmalignant changes of mesenchymal tissue. This paper discusses this rare tumour in a common setting. |
format | Online Article Text |
id | pubmed-3235721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32357212011-12-27 Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar Kinra, Prateek Srinivas, V. Sinha, Kavita Dutta, Vibha Case Rep Med Case Report Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. The neoplasm occurred as a complication of radiotherapy (excessive cumulative radiation dose of 60 Gray) for carcinoma larynx with a latency period of three years. Postradiation spindle cell carcinoma is an uncommon disease manifesting as sarcoma in a previously irradiated field, usually with a latent period of 5 years or more. Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. The two components of the tumour were confirmed using the immunohistochemical staining (cytokeratin and vimentin). Further p53 positivity of the sarcomatous elements aided in ruling out radiation-induced nonmalignant changes of mesenchymal tissue. This paper discusses this rare tumour in a common setting. Hindawi Publishing Corporation 2011 2011-11-30 /pmc/articles/PMC3235721/ /pubmed/22203850 http://dx.doi.org/10.1155/2011/325193 Text en Copyright © 2011 Prateek Kinra et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kinra, Prateek Srinivas, V. Sinha, Kavita Dutta, Vibha Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
title | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
title_full | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
title_fullStr | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
title_full_unstemmed | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
title_short | Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar |
title_sort | post irradiation spindle cell carcinoma of tonsillar pillar |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235721/ https://www.ncbi.nlm.nih.gov/pubmed/22203850 http://dx.doi.org/10.1155/2011/325193 |
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