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Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar

Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. The neoplasm occurred as a complication of radiot...

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Autores principales: Kinra, Prateek, Srinivas, V., Sinha, Kavita, Dutta, Vibha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235721/
https://www.ncbi.nlm.nih.gov/pubmed/22203850
http://dx.doi.org/10.1155/2011/325193
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author Kinra, Prateek
Srinivas, V.
Sinha, Kavita
Dutta, Vibha
author_facet Kinra, Prateek
Srinivas, V.
Sinha, Kavita
Dutta, Vibha
author_sort Kinra, Prateek
collection PubMed
description Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. The neoplasm occurred as a complication of radiotherapy (excessive cumulative radiation dose of 60 Gray) for carcinoma larynx with a latency period of three years. Postradiation spindle cell carcinoma is an uncommon disease manifesting as sarcoma in a previously irradiated field, usually with a latent period of 5 years or more. Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. The two components of the tumour were confirmed using the immunohistochemical staining (cytokeratin and vimentin). Further p53 positivity of the sarcomatous elements aided in ruling out radiation-induced nonmalignant changes of mesenchymal tissue. This paper discusses this rare tumour in a common setting.
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spelling pubmed-32357212011-12-27 Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar Kinra, Prateek Srinivas, V. Sinha, Kavita Dutta, Vibha Case Rep Med Case Report Spindle cell carcinoma of the tonsillar pillar is a rare malignancy. A case of spindle cell carcinoma of the anterior tonsillar pillar in a 59-year-old man is presented. A growth on the anterior tonsillar pillar, measuring 9 × 7 × 6 mm, was resected. The neoplasm occurred as a complication of radiotherapy (excessive cumulative radiation dose of 60 Gray) for carcinoma larynx with a latency period of three years. Postradiation spindle cell carcinoma is an uncommon disease manifesting as sarcoma in a previously irradiated field, usually with a latent period of 5 years or more. Literature is limited to small series. Histologically, this tonsillar growth was composed of a squamous cell carcinoma (epithelial component) and a spindle cell sarcomatous component. The two components of the tumour were confirmed using the immunohistochemical staining (cytokeratin and vimentin). Further p53 positivity of the sarcomatous elements aided in ruling out radiation-induced nonmalignant changes of mesenchymal tissue. This paper discusses this rare tumour in a common setting. Hindawi Publishing Corporation 2011 2011-11-30 /pmc/articles/PMC3235721/ /pubmed/22203850 http://dx.doi.org/10.1155/2011/325193 Text en Copyright © 2011 Prateek Kinra et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kinra, Prateek
Srinivas, V.
Sinha, Kavita
Dutta, Vibha
Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
title Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
title_full Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
title_fullStr Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
title_full_unstemmed Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
title_short Post Irradiation Spindle Cell Carcinoma of Tonsillar Pillar
title_sort post irradiation spindle cell carcinoma of tonsillar pillar
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235721/
https://www.ncbi.nlm.nih.gov/pubmed/22203850
http://dx.doi.org/10.1155/2011/325193
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