Antitumor Activity of a Novel Oncrasin Analogue Is Mediated by JNK Activation and STAT3 Inhibition

BACKGROUND: To optimize the antitumor activity of oncrasin-1, a small molecule identified through synthetic lethality screening on isogenic K-Ras mutant tumor cells, we developed several analogues and determined their antitumor activities. Here we investigated in vitro and in vivo antitumor activity...

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Detalles Bibliográficos
Autores principales: Guo, Wei, Wu, Shuhong, Wang, Li, Wei, Xiaoli, Liu, Xiaoying, Wang, Ji, Lu, Zhimin, Hollingshead, Melinda, Fang, Bingliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236185/
https://www.ncbi.nlm.nih.gov/pubmed/22174819
http://dx.doi.org/10.1371/journal.pone.0028487

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236185/
https://www.ncbi.nlm.nih.gov/pubmed/22174819
http://dx.doi.org/10.1371/journal.pone.0028487

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