Inhibition of the Mitochondrial Enzyme ABAD Restores the Amyloid-β-Mediated Deregulation of Estradiol

Alzheimer's disease (AD) is a conformational disease that is characterized by amyloid-β (Aβ) deposition in the brain. Aβ exerts its toxicity in part by receptor-mediated interactions that cause down-stream protein misfolding and aggregation, as well as mitochondrial dysfunction. Recent reports...

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Detalles Bibliográficos
Autores principales: Lim, Yun-An, Grimm, Amandine, Giese, Maria, Mensah-Nyagan, Ayikoe Guy, Villafranca, J. Ernest, Ittner, Lars M., Eckert, Anne, Götz, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236223/
https://www.ncbi.nlm.nih.gov/pubmed/22174920
http://dx.doi.org/10.1371/journal.pone.0028887

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236223/
https://www.ncbi.nlm.nih.gov/pubmed/22174920
http://dx.doi.org/10.1371/journal.pone.0028887

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