Postnatal Proteasome Inhibition Induces Neurodegeneration and Cognitive Deficiencies in Adult Mice: A New Model of Neurodevelopment Syndrome

Defects in the ubiquitin-proteasome system have been related to aging and the development of neurodegenerative disease, although the effects of deficient proteasome activity during early postnatal development are poorly understood. Accordingly, we have assessed how proteasome dysfunction during earl...

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Detalles Bibliográficos
Autores principales: Romero-Granados, Rocío, Fontán-Lozano, Ángela, Aguilar-Montilla, Francisco Javier, Carrión, Ángel Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236230/
https://www.ncbi.nlm.nih.gov/pubmed/22174927
http://dx.doi.org/10.1371/journal.pone.0028927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236230/
https://www.ncbi.nlm.nih.gov/pubmed/22174927
http://dx.doi.org/10.1371/journal.pone.0028927

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