Peroxisome Proliferator-Activated Receptor-α Activation Decreases Mean Arterial Pressure, Plasma Interleukin-6, and COX-2 While Increasing Renal CYP4A Expression in an Acute Model of DOCA-Salt Hypertension

Peroxisome proliferator-activated receptor-alpha (PPAR-α) activation by fenofibrate reduces blood pressure and sodium retention during DOCA-salt hypertension. PPAR-α activation reduces the expression of inflammatory cytokines, such as interleukin-6 (IL-6). Fenofibrate also induces cytochrome P450 4A...

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Detalles Bibliográficos
Autores principales: Lee, Dexter L., Wilson, Justin L., Duan, Rong, Hudson, Tamaro, El-Marakby, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236317/
https://www.ncbi.nlm.nih.gov/pubmed/22190908
http://dx.doi.org/10.1155/2011/502631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236317/
https://www.ncbi.nlm.nih.gov/pubmed/22190908
http://dx.doi.org/10.1155/2011/502631

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