Knockout of the dhfr-ts Gene in Trypanosoma cruzi Generates Attenuated Parasites Able to Confer Protection against a Virulent Challenge

BACKGROUND: Trypanosoma cruzi is a protozoan parasite that causes severe disease in millions of habitants of developing countries. Currently there is no vaccine to prevent this disease and the available drugs have the consequences of side effects. Live vaccines are likely to be more effective in ind...

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Detalles Bibliográficos
Autores principales: Perez Brandan, Cecilia, Padilla, Angel M., Xu, Dan, Tarleton, Rick L., Basombrio, Miguel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236718/
https://www.ncbi.nlm.nih.gov/pubmed/22180798
http://dx.doi.org/10.1371/journal.pntd.0001418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236718/
https://www.ncbi.nlm.nih.gov/pubmed/22180798
http://dx.doi.org/10.1371/journal.pntd.0001418

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