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A LigA Three-Domain Region Protects Hamsters from Lethal Infection by Leptospira interrogans
The leptospiral LigA protein consists of 13 bacterial immunoglobulin-like (Big) domains and is the only purified recombinant subunit vaccine that has been demonstrated to protect against lethal challenge by a clinical isolate of Leptospira interrogans in the hamster model of leptospirosis. We determ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236721/ https://www.ncbi.nlm.nih.gov/pubmed/22180800 http://dx.doi.org/10.1371/journal.pntd.0001422 |