FAK Deletion Promotes p53-Mediated Induction of p21, DNA-Damage Responses and Radio-Resistance in Advanced Squamous Cancer Cells

Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that is elevated in a variety of human cancers. While FAK is implicated in many cellular processes that are perturbed in cancer, including proliferation, actin and adhesion dynamics, polarisation and invasion, there is only some limited in...

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Detalles Bibliográficos
Autores principales: Graham, Kathryn, Moran-Jones, Kim, Sansom, Owen J., Brunton, Valerie G., Frame, Margaret C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237418/
https://www.ncbi.nlm.nih.gov/pubmed/22194793
http://dx.doi.org/10.1371/journal.pone.0027806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237418/
https://www.ncbi.nlm.nih.gov/pubmed/22194793
http://dx.doi.org/10.1371/journal.pone.0027806

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