EZH2 Codon 641 Mutations are Common in BCL2-Rearranged Germinal Center B Cell Lymphomas

Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification. As an initial step toward screening patients for cancer...

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Detalles Bibliográficos
Autores principales: Ryan, Russell J. H., Nitta, Mai, Borger, Darrell, Zukerberg, Lawrence R., Ferry, Judith A., Harris, Nancy Lee, Iafrate, A. John, Bernstein, Bradley E., Sohani, Aliyah R., Le, Long Phi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237460/
https://www.ncbi.nlm.nih.gov/pubmed/22194861
http://dx.doi.org/10.1371/journal.pone.0028585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237460/
https://www.ncbi.nlm.nih.gov/pubmed/22194861
http://dx.doi.org/10.1371/journal.pone.0028585

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