IGF-1 and PDGF-bb Suppress IL-1β-Induced Cartilage Degradation through Down-Regulation of NF-κB Signaling: Involvement of Src/PI-3K/AKT Pathway

OBJECTIVE: Interleukin-1β (IL-1β) is a pro-inflammatory cytokine that plays a key role in the pathogenesis of osteoarthritis (OA). Growth factors (GFs) capable of antagonizing the catabolic actions of cytokines may have therapeutic potential in the treatment of OA. Herein, we investigated the potent...

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Detalles Bibliográficos
Autores principales: Montaseri, Azadeh, Busch, Franziska, Mobasheri, Ali, Buhrmann, Constanze, Aldinger, Constance, Rad, Jafar Soleimani, Shakibaei, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237481/
https://www.ncbi.nlm.nih.gov/pubmed/22194879
http://dx.doi.org/10.1371/journal.pone.0028663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237481/
https://www.ncbi.nlm.nih.gov/pubmed/22194879
http://dx.doi.org/10.1371/journal.pone.0028663

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