Epigenetic Silencing of IRF7 and/or IRF5 in Lung Cancer Cells Leads to Increased Sensitivity to Oncolytic Viruses

Defective IFN signaling results in loss of innate immunity and sensitizes cells to enhanced cytolytic killing after Vesticular Stomatitis Virus (VSV) infection. Examination of the innate immunity status of normal human bronchial epithelial cells Beas2B and 7 lung cancer cells revealed that the abrog...

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Detalles Bibliográficos
Autores principales: Li, Qunfang, Tainsky, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237484/
https://www.ncbi.nlm.nih.gov/pubmed/22194884
http://dx.doi.org/10.1371/journal.pone.0028683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237484/
https://www.ncbi.nlm.nih.gov/pubmed/22194884
http://dx.doi.org/10.1371/journal.pone.0028683

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