AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

Thioredoxin-interacting protein (TXNIP) regulates critical biological processes including inflammation, stress and apoptosis. TXNIP is upregulated by glucose and is a critical mediator of hyperglycemia-induced beta-cell apoptosis in diabetes. In contrast, the saturated long-chain fatty acid palmitat...

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Detalles Bibliográficos
Autores principales: Shaked, Maayan, Ketzinel-Gilad, Mali, Cerasi, Erol, Kaiser, Nurit, Leibowitz, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237554/
https://www.ncbi.nlm.nih.gov/pubmed/22194917
http://dx.doi.org/10.1371/journal.pone.0028804

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237554/
https://www.ncbi.nlm.nih.gov/pubmed/22194917
http://dx.doi.org/10.1371/journal.pone.0028804

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