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AMP-Activated Protein Kinase (AMPK) Mediates Nutrient Regulation of Thioredoxin-Interacting Protein (TXNIP) in Pancreatic Beta-Cells

Thioredoxin-interacting protein (TXNIP) regulates critical biological processes including inflammation, stress and apoptosis. TXNIP is upregulated by glucose and is a critical mediator of hyperglycemia-induced beta-cell apoptosis in diabetes. In contrast, the saturated long-chain fatty acid palmitat...

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Detalles Bibliográficos
Autores principales:	Shaked, Maayan, Ketzinel-Gilad, Mali, Cerasi, Erol, Kaiser, Nurit, Leibowitz, Gil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237554/ https://www.ncbi.nlm.nih.gov/pubmed/22194917 http://dx.doi.org/10.1371/journal.pone.0028804

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