Hyperglycemia Enhances IGF-I–Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKCζ-Dependent Manner in Vascular Smooth Muscle Cells

IGF-I–stimulated sarcoma viral oncogene (Src) activation during hyperglycemia is required for propagating downstream signaling. The aim of the current study was to determine the mechanism by which hyperglycemia enhances IGF-I–stimulated Src activation and the role of NADPH oxidase 4 (Nox4) and prote...

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Detalles Bibliográficos
Autores principales: Xi, Gang, Shen, Xinchun, Maile, Laura A., Wai, Christine, Gollahon, Katherine, Clemmons, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237650/
https://www.ncbi.nlm.nih.gov/pubmed/22148072
http://dx.doi.org/10.2337/db11-0990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237650/
https://www.ncbi.nlm.nih.gov/pubmed/22148072
http://dx.doi.org/10.2337/db11-0990

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