The ATP-Sensitive K(+) Channel ABCC8 S1369A Type 2 Diabetes Risk Variant Increases MgATPase Activity

Pancreatic β-cell ATP-sensitive K(+) (K(ATP)) channels are composed of Kir6.2 and SUR1 subunits encoded by the KCNJ11 and ABCC8 genes, respectively. Although rare monogenic activating mutations in these genes cause overt neonatal diabetes, the common variants E23K (KCNJ11) and S1369A (ABCC8) form a...

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Detalles Bibliográficos
Autores principales: Fatehi, Mohammad, Raja, Mobeen, Carter, Christian, Soliman, Daniel, Holt, Andrew, Light, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Genetics/Genomes/Proteomics/Metabolomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237651/
https://www.ncbi.nlm.nih.gov/pubmed/22187380
http://dx.doi.org/10.2337/db11-0371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237651/
https://www.ncbi.nlm.nih.gov/pubmed/22187380
http://dx.doi.org/10.2337/db11-0371

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